Sarah M. from Des Moines, Iowa
booked a strategy call
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Your POTS Isn't "Just Anxiety." It's Autonomic Dysregulation — Discover the Real Drivers
Backed by Actual Lab Data, Not Guesswork. Autonomic Function. Adrenals. Blood Volume. Mast Cells. Gut Health. Nutrients. We measure all of it.
Autonomic Dysfunction
Autonomic Labs
Supportive NutritionFind Out If You Qualify For Our Functional POTS Protocol
Do You Experience Any Of These POTS Symptoms?
Select every statement that applies to you. Your severity grade updates below as you check boxes.
Why Conventional Medicine Is Failing POTS Sufferers
You were told it's 'just anxiety' or 'deconditioning' and handed beta blockers or salt pills. Year after year, the symptoms persist — and nobody ever tested your autonomic and adrenal function.
POTS is autonomic nervous system dysregulation
Your adrenals, blood volume, mast cells, and gut all regulate autonomic function. Untreated dysregulation keeps you stuck in standing intolerance.
Suppressing Heart Rate, Not Restoring the Nervous System
Beta blockers lower the number but never address why your autonomic nervous system is dysregulated — adrenals, blood volume, mast cells, and gut.
Adrenal & Blood Volume Dysfunction
Low cortisol and low blood volume drive the standing intolerance. Standard care rarely tests or addresses these root drivers.
Mast Cell Activation
Mast cell instability triggers flares of POTS symptoms — yet mast cell testing is almost never run in conventional care.
The System Misses the Real Drivers
Standard panels check basic blood counts alone — skipping adrenal function, blood volume, mast cell markers, and gut health.
The System Is Not Built to Resolve POTS
Symptom Management, Not Root Cause Resolution
You're handed beta blockers and salt pills. Year after year symptoms persist and nobody asks why your autonomic system is dysregulated.
Incomplete Diagnostic Workups
Standard workups check basic blood counts, skipping adrenal function, blood volume, mast cell markers, and gut health.
Misdiagnosed as 'Just Anxiety'
POTS is routinely dismissed as anxiety or deconditioning — leaving the real autonomic drivers untreated for years.
No Pathway to Autonomic Restoration
Conventional care focuses on lifelong symptom management rather than restoring the nervous system balance you need to function.
A Natural Functional Approach to Autonomic Restoration
Comprehensive Autonomic Investigation
We run adrenal/cortisol panels, blood volume markers, mast cell testing, gut health, and nutrients — not just basic labs.
Personalized Support Protocol
A therapeutic nutrition plan built around your specific adrenal, blood volume, and mast cell needs — with targeted electrolyte support.
Autonomic & Adrenal Support
Evidence-based nutraceuticals like adrenal support, electrolytes, anti-inflammatory botanicals, and gut repair — dosed precisely from your labs.
Ongoing Monitoring & Restoration
Regular follow-up labs and protocol adjustments ensure you're progressing toward autonomic balance and restored energy.
We Look Where Others Don't
Low cortisol and adrenal dysfunction directly drive the standing intolerance and fatigue of POTS.
Low blood volume and electrolyte imbalance drive the lightheadedness and rapid heart rate on standing.
Mast cell activation triggers POTS flares — yet this testing is almost never run in conventional care.
Gut dysbiosis and histamine intolerance drive mast cell activation and autonomic flares.
Nutrient deficiencies and mitochondrial dysfunction worsen fatigue and autonomic instability.
POTS often overlaps with autoimmunity and chronic inflammation — these markers guide your protocol.
Standard workups check basic blood counts alone — skipping adrenal function, blood volume, mast cell markers, and gut health — leaving the true POTS drivers hidden.
of patients report significant improvement with root-cause functional intervention
Four Pillars of Our POTS Protocol
Therapeutic Nutrition
- Electrolyte & blood-volume support
- Anti-inflammatory whole foods
- Low-histamine nutrition strategy
- Gut lining repair support
Targeted Supplementation
- Adrenal & cortisol support
- Electrolytes & hydration
- Anti-inflammatory botanicals
- Magnesium & nutrient repletion
Adrenal & Autonomic Care
- Cortisol rhythm optimization
- Mast cell stabilization
- Sleep & circadian restoration
- Gradual reconditioning protocols
Gut & Immune Restoration
- GI-Map guided microbiome repair
- Histamine-clearance support
- Leaky gut sealing protocol
- Immune modulation
Clinical Improvement Rates
Dr. Brandon Mannie
Board-Certified Functional Medicine Practitioner
Dr. Brandon Mannie is a board-certified functional medicine practitioner with over 400 hours of post-graduate training in clinical nutrition and functional medicine. He graduated from Northwestern Health Sciences University in 2004 and has been in private practice ever since.
Over the past 20+ years, Dr. Mannie has consulted with more than 3,000 patients — people who were told their labs were "normal," yet still felt far from well. His approach goes beyond symptom management: he investigates the root causes driving chronic illness and builds personalized protocols that restore true, lasting health.
Dr. Mannie operates a fully virtual telehealth practice, serving patients nationwide. His clinical expertise includes type 2 diabetes, insulin resistance, metabolic syndrome, weight loss resistance, and neuropathy.
"I've seen patients who were dismissed for years finally get real answers and real results. That's why I do this work."
Real People. Real Results.
These are the stories of patients who were told there was nothing more that could be done — and who chose to look deeper.
"I was told I'd just have to live with the fatigue. Dr. Mannie proved them wrong."
"After 4 years on Metformin and still feeling exhausted, Dr. Mannie found my issue was cellular resistance and gut inflammation. Within 90 days on his protocol, my energy is back and I've lost 15 pounds that wouldn't budge before."
"I was told I'd just have to live with the fatigue. Dr. Mannie proved them wrong. Within 90 days on his protocol, my energy is back and I've lost 15 pounds that wouldn't budge before."
"I was told my fasting glucose was 'normal' — meaning they had no idea why I felt so terrible. The functional labs revealed elevated fasting insulin and systemic inflammation. The targeted protocol changed everything."
"As a nurse, I was skeptical of anything outside conventional medicine. But when conventional medicine failed my Type 2 Diabetes for three years, I had nothing to lose. The root cause approach is exactly what I wish I had been taught."
"The difference between this approach and everything else I tried is that it actually makes sense. They found the cause — chronic gut inflammation and heavy metal toxicity triggering my immune system — and addressed it systematically."
"I had given up on ever having energy to play with my grandkids. The functional protocol — particularly the gut healing and targeted nutrient support — gave me my life back."
"Three specialists and a decade of suffering. One functional consultation changed the trajectory completely. My metabolic dysfunction had a root cause — and now it has a solution."
"I lost 47 pounds with Dr. Mannie's protocol without starving or resorting to injections. I sleep better, my anxiety is down, and I have boundless energy throughout the day."
"I was told I'd just have to live with the fatigue. Dr. Mannie proved them wrong. Within 90 days on his protocol, my energy is back and I've lost 15 pounds that wouldn't budge before."
"I was told my fasting glucose was 'normal' — meaning they had no idea why I felt so terrible. The functional labs revealed elevated fasting insulin and systemic inflammation. The targeted protocol changed everything."
"As a nurse, I was skeptical of anything outside conventional medicine. But when conventional medicine failed my Type 2 Diabetes for three years, I had nothing to lose. The root cause approach is exactly what I wish I had been taught."
"The difference between this approach and everything else I tried is that it actually makes sense. They found the cause — chronic gut inflammation and heavy metal toxicity triggering my immune system — and addressed it systematically."
"I had given up on ever having energy to play with my grandkids. The functional protocol — particularly the gut healing and targeted nutrient support — gave me my life back."
"Three specialists and a decade of suffering. One functional consultation changed the trajectory completely. My metabolic dysfunction had a root cause — and now it has a solution."
"I lost 47 pounds with Dr. Mannie's protocol without starving or resorting to injections. I sleep better, my anxiety is down, and I have boundless energy throughout the day."
Frequently Asked Questions
Ready to Stop Managing POTS and Start Restoring Balance?
Book a 1-on-1 strategy call with Dr. Brandon Mannie's clinical team. No obligation, no hard sell — just clinical clarity on your path to autonomic restoration.
