Sarah M. from Des Moines, Iowa
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Backed by Actual Lab Data, Not Guesswork. GI-Map. Leaky Gut Markers. SIBO Breath. Food Sensitivities. We measure all of it.
Digestive Distress
Gut-Healing Nutrition
Gut-Brain FogSelect every statement that applies to you. Your severity grade updates below as you check boxes.
Over 70 million Americans suffer from digestive disease — yet conventional care relies on symptom labels and acid blockers. Here is why the standard approach fails.

When the microbiome breaks down, inflammation floods every system — from your brain to your joints to your skin.
Conventional doctors label bloating and irregularity as IBS — a symptom bucket, not a diagnosis. It tells you nothing about the dysbiosis, leaky gut, or SIBO actually driving your suffering.
A damaged gut can't absorb nutrients. The result is crushing fatigue, brain fog, and mood swings — because 95% of your serotonin and most of your immune system live in your gut.
Acid blockers and repeated antibiotics wipe out your microbiome, starve you of stomach acid, and feed pathogenic overgrowth — making the root cause worse with every prescription.
Hidden dysbiosis, intestinal permeability, SIBO, parasites, and Candida overgrowth are almost never tested — yet they drive the inflammation behind dozens of chronic conditions.
Antacids, antispasmodics, and antibiotics mask bloating and reflux while leaving dysbiosis, leaky gut, and microbial overgrowth completely untouched.
Standard workups check basic bloodwork alone, omitting DNA stool analysis (GI-Map), leaky gut markers, breath testing, and food sensitivity panels.
Conventional stool cultures miss 90% of the microbiome. Patients sit inside 'normal' results for years while pathogens and inflammation destroy the gut lining.
Conventional care focuses on lifelong medication adjustments, never addressing barrier repair, microbial reinoculation, or the 5R healing protocol.

We run a deep-dive functional gut panel — GI-Map stool DNA, leaky gut markers, breath testing, and food sensitivities — to map your exact microbial roadblocks.
We build a targeted protocol combining therapeutic nutrition, evidence-based nutraceuticals, and antimicrobials to rebalance your microbiome and digestion.
We repair intestinal permeability (leaky gut), calm systemic inflammation, and reinoculate beneficial bacteria to halt immune overactivation.
We track progress with repeat functional labs, symptom mapping, and strategy reviews — adapting your protocol as your microbiome rebalances.
Comprehensive DNA stool analysis reveals the exact balance of beneficial and pathogenic microbes driving your digestive breakdown.
Leaky gut markers show whether undigested food and toxins are leaking into your bloodstream, triggering systemic inflammation.
Measures whether you actually break down and absorb nutrients — low enzyme or bile output starves every cell in your body.
Chronic gut inflammation destroys the microbiome and the intestinal lining — these markers quantify the fire inside.
Hidden food sensitivities trigger chronic immune reactions that inflame the gut and silently block healing.
Small intestinal bacterial overgrowth ferments your food into gas, driving bloating, malabsorption, and nutrient deficiency.

Standard workups rarely run DNA stool analysis, leaky gut markers, or breath testing — leaving dysbiosis, SIBO, and intestinal permeability completely unaddressed.
Root cause detection rate in patients previously told labs were "normal"

Board-Certified Functional Medicine Practitioner
Dr. Brandon Mannie is a board-certified functional medicine practitioner with over 400 hours of post-graduate training in clinical nutrition and functional medicine. He graduated from Northwestern Health Sciences University in 2004 and has been in private practice ever since.
Over the past 20+ years, Dr. Mannie has consulted with more than 3,000 patients — people who were told their labs were "normal," yet still felt far from well. His approach goes beyond symptom management: he investigates the root causes driving chronic illness and builds personalized protocols that restore true, lasting health.
Dr. Mannie operates a fully virtual telehealth practice, serving patients nationwide. His clinical expertise includes type 2 diabetes, insulin resistance, metabolic syndrome, weight loss resistance, and neuropathy.
"I've seen patients who were dismissed for years finally get real answers and real results. That's why I do this work."
These are the stories of patients who were told there was nothing more that could be done — and who chose to look deeper.

"I was told I'd just have to live with the fatigue. Dr. Mannie proved them wrong."
"After 4 years on Metformin and still feeling exhausted, Dr. Mannie found my issue was cellular resistance and gut inflammation. Within 90 days on his protocol, my energy is back and I've lost 15 pounds that wouldn't budge before."
"I was told I'd just have to live with the fatigue. Dr. Mannie proved them wrong. Within 90 days on his protocol, my energy is back and I've lost 15 pounds that wouldn't budge before."
"I was told my fasting glucose was 'normal' — meaning they had no idea why I felt so terrible. The functional labs revealed elevated fasting insulin and systemic inflammation. The targeted protocol changed everything."
"As a nurse, I was skeptical of anything outside conventional medicine. But when conventional medicine failed my Type 2 Diabetes for three years, I had nothing to lose. The root cause approach is exactly what I wish I had been taught."
"The difference between this approach and everything else I tried is that it actually makes sense. They found the cause — chronic gut inflammation and heavy metal toxicity triggering my immune system — and addressed it systematically."
"I had given up on ever having energy to play with my grandkids. The functional protocol — particularly the gut healing and targeted nutrient support — gave me my life back."
"Three specialists and a decade of suffering. One functional consultation changed the trajectory completely. My metabolic dysfunction had a root cause — and now it has a solution."
"I lost 47 pounds with Dr. Mannie's protocol without starving or resorting to injections. I sleep better, my anxiety is down, and I have boundless energy throughout the day."
"I was told I'd just have to live with the fatigue. Dr. Mannie proved them wrong. Within 90 days on his protocol, my energy is back and I've lost 15 pounds that wouldn't budge before."
"I was told my fasting glucose was 'normal' — meaning they had no idea why I felt so terrible. The functional labs revealed elevated fasting insulin and systemic inflammation. The targeted protocol changed everything."
"As a nurse, I was skeptical of anything outside conventional medicine. But when conventional medicine failed my Type 2 Diabetes for three years, I had nothing to lose. The root cause approach is exactly what I wish I had been taught."
"The difference between this approach and everything else I tried is that it actually makes sense. They found the cause — chronic gut inflammation and heavy metal toxicity triggering my immune system — and addressed it systematically."
"I had given up on ever having energy to play with my grandkids. The functional protocol — particularly the gut healing and targeted nutrient support — gave me my life back."
"Three specialists and a decade of suffering. One functional consultation changed the trajectory completely. My metabolic dysfunction had a root cause — and now it has a solution."
"I lost 47 pounds with Dr. Mannie's protocol without starving or resorting to injections. I sleep better, my anxiety is down, and I have boundless energy throughout the day."
Book a complimentary 1-on-1 strategy call with Dr. Brandon Mannie's clinical team. No obligation, no hard sell — just clinical clarity on your path forward.